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A cruise from San Diego is the perfect way to see the delights of the Mexican Riviera to the south or further up the Californian coast along the western seaboard all the way north to Vancouver, even as a one-way trip. Alternatively, there are also many itineraries departing for round-trip sailings to Hawaii. Typically with a duration of 7 to 10 days, whether you're a couple, family or solo traveller, and with plenty of flights options out of the UK to San Diego International Airport, you'll easily find the best cruise departing San Diego for you for 2026, 2027 and 2028 with Scotland's Cruise Centre. Call one of our friendly Cruise Experts and book your dream San Diego cruise adventure today!
Luxury
Crystal Symphony 24 August 2026 12 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - Puerto Vallarta - Acajutla - San Juan del Sur - Puntarenas - Manta - Guayaquil
Cruise Only from
Luxury
Crystal Symphony 24 August 2026 32 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - Puerto Vallarta - Acajutla - San Juan del Sur - Puntarenas - Manta - Guayaquil - Panama Canal...
Cruise Only from
Nieuw Amsterdam 02 October 2026 16 nights
Itinerary: San Diego - Puerto Vallarta - Santa Cruz - Puerto Chiapas - Puerto Quetzal - Acajutla - Cartagena - Half Moon Cay - Fort Lauderdale
Cruise Only from
Includes extra savings of up to £194pp
Disney Wonder 03 October 2026 7 nights
Itinerary: San Diego - Puerto Vallarta - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Serenade of the Seas 04 October 2026 7 nights
Itinerary: San Diego - La Paz - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Includes extra savings of up to £30pp
Zaandam 08 October 2026 7 nights
Itinerary: San Diego - Cabo San Lucas - La Paz - Loreto - San Diego
Cruise Only from
Includes extra savings of up to £78pp
Eurodam 08 October 2026 16 nights
Itinerary: San Diego - Cabo San Lucas - Acapulco - Santa Cruz - Puerto Chiapas - Puerto Quetzal - Puntarenas - Oranjestad - Fort Lauderdale
Cruise Only from
Includes extra savings of up to £201pp
Zaandam 15 October 2026 35 nights
Itinerary: San Diego - Nawiliwili - Honolulu - Kahului - Kona - Fanning Island - Rangiroa - Huahine - Bora Bora - Raiatea...
Call us now on 0800 019 0053
Serenade of the Seas 18 October 2026 7 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - La Paz - San Diego
Cruise Only from
Includes extra savings of up to £21pp
Disney Magic 19 October 2026 5 nights
Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Koningsdam 20 October 2026 11 nights
Itinerary: San Diego - Manzanillo - Puerto Vallarta - Mazatlan - La Paz - Loreto - Cabo San Lucas - San Diego
Cruise Only from
Includes extra savings of up to £112pp
Disney Wonder 22 October 2026 5 nights
Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Disney Magic 24 October 2026 6 nights
Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Serenade of the Seas 25 October 2026 7 nights
Itinerary: San Diego - La Paz - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Includes extra savings of up to £22pp
Disney Wonder 27 October 2026 6 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - San Diego
Cruise Only from
Disney Magic 30 October 2026 7 nights
Itinerary: San Diego - Puerto Vallarta - Cabo San Lucas - Ensenada - San Diego
Cruise Only from
Serenade of the Seas 01 November 2026 7 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego
Cruise Only from
Includes extra savings of up to £21pp
Disney Magic 06 November 2026 14 nights
Itinerary: San Diego - Cabo San Lucas - Puerto Vallarta - Panama Canal - Cartagena - George Town - Galveston
Cruise Only from
Serenade of the Seas 08 November 2026 7 nights
Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego
Cruise Only from
Koningsdam 14 November 2026 7 nights
Itinerary: San Diego - Catalina Island - San Francisco - Ensenada - San Diego
Cruise Only from
Includes extra savings of up to £74pp
Sarah Lee was excellent very helpful and explained everything in great detail.
Trusted Customer / May 2026
The girl, Shona, was very pleasant and helpful. Got us what we wanted and the best deal. I wouldn't hesitate to book with them again. I'll be looking as soon as we return
Mrs Boyd / April 2026
Great knowledgeable staff offering great deals in particular Heidi Cassidy. Great advice and makes booking simple.
Mrs Ross / April 2026
At Scotland's Cruise Centre there are a number of ways you can contact us meaning that all you have to do is choose the option which is most convenient to you.
Request a Callback
Get A Quote
At Scotland's Cruise Centre there are a number of ways you can contact us meaning that all you have to do is choose the option which is most convenient to you.
Get A Quote
Request A Callback
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